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Clonidine for Sedation of Paediatric Patients in the Intensive Care Unit

CloSed is a 5-year project funded under the Seventh Framework Programme (FP7) with an international Consortium comprising 10 European partners and coordinated by Assoc. Prof. Antje Neubert, University Hospital of Erlangen.

The project aims to conduct a multicentre clinical trial of clonidine in children until the age of 18. Indeed, despite its widespread use in Pediatric Intensive Care Units (PICU), this drug still lacks authorisation for paediatric use. A parenteral age-appropriate formulation of clonidine for sedation in PICU will be developed and tested in order to obtain a Pediatric Use Marketing Authorisation (PUMA).

Latest News

22Jun

CloSed Newsletter #5

The fifth issue of the CloSed six-monthly newsletter has been published and is available at this link. Use the QR-code to... Read More →
18Jun

Site Initiation Visit at UKER

On April 6th 2016, the site initiation visit (SIV) at University Hospital Erlangen – Department of Paediatrics and Adolescent Medicine... Read More →

European Research in Paediatrics

EU Paediatric Regulation includes provisions for funding of research into off-patent medicines leading to PUMAs. In this context, the EU launched several calls under FP7 to develop age-appropriate formulations and/or delivery systems of off-patent drugs used in paediatrics, and the CloSed project has been selected for funding.

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